ivive.app
Human hepatic clearance from in-vitro CLint, with the error band measured on known drugs.
| Endpoint | https://api.ivive.app/mcp/ (streamable-http) |
|---|---|
| Registry version | 1.0.2 |
| Now | 6 tools · grade B (89) · pin ts_851e95b4b45b68fe2599ae1361c84fe4 · protocol 2025-06-18 |
| First / last listed | 2026-10-25 00:14 UTC / 2026-10-25 00:14 UTC |
| Grade over time | 2026-10-25: B (89), 6 tools |
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Tools: predict_inputs calc_clhep target_clint input_sensitivity similar_drugs scale_to_human
predict_inputs | Predict fu,p and fu,inc from a SMILES, with structure-only human CL and Vss as second opinions. Predictions, not measurements; check the applicability verdict. params: smiles*, assay_type, concentration |
calc_clhep | Hepatic and plasma clearance from in-vitro CLint, fu,mic and fu,p (IVIVE), with the observed-CL band and applicability warnings. If fu,p or fu,mic came from predict_inputs, tell the user the result rests on predicted inputs. params: clint*, fu_mic*, fu_p*, rb, species*, model, assay_type, correction_id, clint_censored |
target_clint | The in-vitro CLint an assay must read for a compound to reach a target plasma clearance (mL/min/kg): calc_clhep run backwards, e.g. to set a CLint cut-off for a screening cascade. Needs fu,mic and fu,p; refuses a target at or above the liver blood flow ceiling and returns that ceiling. Uncorrected IVIVE, so no error band. params: target_clp*, fu_mic*, fu_p*, rb, species*, model, assay_type |
input_sensitivity | How far plasma CL moves as each input is varied over a range, e.g. a predicted fu,p over its 50% range. params: clint*, fu_mic*, fu_p*, rb, species*, model, assay_type, correction_id, clint_censored, clint_range, fu_mic_range, fu_p_range |
similar_drugs | Nearest reference drugs to a SMILES (Tanimoto, Morgan radius 2), each with measured human plasma CL and the CL IVIVE predicted from its measured inputs. Use it to judge how far to trust calc_clhep for this chemotype: if IVIVE missed on the neighbours, expect it to miss here. Returns neighbours only, not a prediction for the query. params: smiles*, n |
scale_to_human | Predict human plasma CL from observed animal in-vivo CL (rat, dog, monkey), every applicable method with its measured error. Observed animal CL only, never predicted. params: animals*, fu_p_human |
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